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The introduction of effective oral options lowers barriers to use for patients, which is likely to accelerate demand, pushing this already high-cost category into a new phase of coverage complexity

Even positive changes, such as weight loss, can stress the body and lead to temporary menstrual irregularities

Patients whose cancer has the wild-type RAS protein and who have previously received an anti-EGFR therapy are also eligible for the new combination

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Persistent halitosis despite good oral hygiene warrants a dental review first, as oral and dental causes such as gum disease are the most common reason for ongoing bad breath

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